Why Cholines May Be the Most Important Nootropic You Take

There are currently seven known types of nootropics: racetams, ampakines, Vitamin B derivatives, peptides, ampakines, natural nootropics, smart drugs, and choline nootropics. This article will explain what choline nootropics are, how they work, and why they are so important. We will also discuss the current evidence that suggests more people are deficient of this essential nutrient than what was previously thought.

What is Choline?

Choline is a natural substance that is necessary for the brain’s neurotransmitters to function. It’s also needed for lipid transport as well as maintaining cell structure and cell membrane signaling function.

Our bodies produce this chemical naturally, but we can develop a deficiency due to both external and genetic causes. This makes it difficult to select a specific dietary recommendation for choline. Since individual requirements are so varied, a recommended adequate intake is advised instead.

According to the Linus Pauling Institute, the recommended intake of choline is 425 mg per day for women and 550 mg per day for men. Pregnant women are one segment of the population that should pay particular attention to their choline intake as it is vital for fetal brain and spine development. Remember to always consult a licensed medical provider before taking supplements while pregnant.

What Are the Symptoms of Choline Deficiency?

The medical community has conducted in-depth studies on choline deficiency in adult men and women. The results showed that patients with induced choline deficiency developed a form of liver disease called nonalcoholic fatty liver disease.

Nonalcoholic fatty liver disease is associated with many of the health problems plaguing Americans today, including but not limited to:

  • chronic obesity
  • lipid disorders
  • high blood pressure
  • insulin resistance
  • a remarkable increase in cirrhosis and liver cancer


When the medically induced choline deficiency was reversed with the administration of choline, the damage was reversed.

How Choline Helps Our Brains

Choline is vital to our brain functioning as well—so vital in fact that if it’s absent during fetal development, neural tube defects become a very serious risk. On the other end of the spectrum, studies have shown that choline supplementation during fetal development improves performance for spatial memory tests even months after it’s no longer being consumed.

While research is ongoing regarding the effects of choline supplementation in older adults, there have been many positive studies that show improvements. For instance, a positive correlation was found between dietary intake of choline and verbal and visual memory test results.

Is it Possible to Take Too Much Choline?

Yes, it is. Intakes of greater than 7,500 mg of choline can cause:

  • a drop in blood pressure
  • gastrointestinal problems
  • sweating

For these reasons, it’s best to keep intake under the tolerable level of 3,500 mg per day.

The effectiveness of choline as a smart drug is still being studied, but it’s undeniable that we can suffer serious health effects if we don’t get enough of this nutrient. Both the physical and developmental effects of choline deficiency are readily apparent in the American population.

Obesity is rampant, fatty liver disease could soon overtake alcoholic liver disease, and millions of Americans suffer from diabetes. Choline supplementation will very likely not solve these problems alone, but because of emerging research, many are arguing that we can’t solve the problem without choline either.

The ramifications of choline deficiency are clear, and many are moving forward with supplementation as scientists continue their research. Those who are interested in learning more about choline and its benefits can visit Nootropics Expert for in-depth research and discussion on this nootropic supplement.


Image courtesy of [suphakit73] at FreeDigitalPhotos.net

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