Treatment & Prevention of Glucocorticoid-induced Osteoporosis

Treatment & Prevention of Glucocorticoid-induced Osteoporosis


We know by now that we need to eat the right foods, need to work out, and do stuff that is healthy for us. Because maintaining good health does not happen by accident, it requires work and smart lifestyle choices. But sometimes when we wake up at 6 am to hit the gym before work or shunning the donuts in breakfast, it’s easy to lose sight of for what are we doing all these. So here are some top articles choices that can keep you motivated to lead a healthy lifestyle and keep diseases at bay.

Treatment & Prevention of Glucocorticoid-induced Osteoporosis

Osteoporosis is a troublesome health problem and it should always be treated and prevented (whenever possible) appropriately. If any patient has to receive long term (more than 3 months) treatment with glucocorticoids, the patient should be evaluated for status of the skeleton by bone mass measurement before starting treatment. The modifiable risk factors of osteoporosis should be identified and precaution should be taken. Evaluation should include 24 hours urine calcium estimation. Ideally bone mass measurement should be done at both the spine and hip using DXA (dual-energy x-ray absorptiometry). If only one site is measured it should be hip for individuals more than 60 years and hip for individuals less than 60 years of age.

Treatment of glucocorticoid-induced osteoporosis:

Among all the medications used for treatment of osteoporosis, only bisphosphonates are effective in reducing risk of fractures in glucocorticoid-induced osteoporosis. Bisphosphonates can reduce risk fracture glucocorticoid-induced osteoporosis, as seen in several clinical trials. Risedronate and alendronate are equally effective in reducing vertebral fracture risk by more than 2/3rd (approximately 70%).

Other medications have some supportive role, e.g. thiazides can reduce calcium loss in urine although the therapeutic benefit in preventing/reducing fracture is not clear, hormones (such as estrogen) have bone-sparing effects, and parathyroid hormones can cause substantial bone mass increase. True role of all these agents are not clear and being investigated.

Prevention of Glucocorticoid-induced Osteoporosis:

Hopefully the bone loss and fracture due to bone loss and in glucocorticoid-induced osteoporosis can be prevented. The lowest possible effective dose of glucocorticoid should be used. Topical and inhalation routes should be used whenever practicable, as these routes are comparatively safer than other systemic routes.

The modifiable risk factors of osteoporosis should be reduced as much as possible, such as quitting smoking, quitting (or reducing) alcohol consumption, doing regular physical exercise, especially weight-bearing exercise.

All patients receiving long term glucocorticoid therapy should be given adequate calcium and vitamin D supplementation, if diet is not adequate.

Avatar for admin

Related Posts

2 Comments

  • Avatar for James
    James March 03, 2011 04.37 pm

    The AlgaeCal Bone Health Program is a natural osteoporosis treatment that combines all of the above advice.This natural osteoporosis treatment consists of AlgaeCal Plus, Strontium Boost and weight bearing exercise.

    AlgaeCal Plus is the world’s only plant source calcium and It also includes magnesium, trace minerals, vitamin D3 and vitamin k2. Strontium Boost is a supplement consisting of strontium citrate, learn more about strontium, a powerful bone building mineral.

  • Avatar for Bryant Davari
    Bryant Davari September 26, 2012 06.55 pm

    Magnificent writing! You have hit the nail on the head with your viewpoints in this article. I think you did a good job with this.

Leave a Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Loading...