How Bisphosphonates Work

How Bisphosphonates Work


We know by now that we need to eat the right foods, need to work out, and do stuff that is healthy for us. Because maintaining good health does not happen by accident, it requires work and smart lifestyle choices. But sometimes when we wake up at 6 am to hit the gym before work or shunning the donuts in breakfast, it’s easy to lose sight of for what are we doing all these. So here are some top articles choices that can keep you motivated to lead a healthy lifestyle and keep diseases at bay.

How Bisphosphonates Work

Bisphosphonates (BPNs) belong to a group of medications commonly used usually for treatment of osteoporosis and other diseases of bones, because they are useful in preventing loss of bone mass. Currently bisphosphonates are the most commonly prescribed medicines for osteoporosis. They are known as bisphosphonates, because they contain two (bis means two) phosphonate (PO3) molecules in their chemical structure.

How bisphosphonates act?

Bisphosphonates or BPNs inhibit osteoclast mediated bone loss (known as bone resorption) by following mechanisms:

  • Bisphosphonates inhibit the differentiation of monocyte macrophage precursors into osteoclasts. New bone formation and bone loss takes place constantly in bones. Osteoblasts are cells responsible for new bone mass formation and osteoclasts are the cells responsible for bone loss or bone resorption. Normally there is fine balance of function between osteoblasts and osteoclasts. Osteoclasts are derived from monocyte macrophages and bisphosphonates by inhibiting new osteoclast formation prevent bone resorption of bone loss.
  • Bisphosphonates accelerates apoptosis. Apoptosis is programmed cell death of osteoblasts, which helps in reducing bone loss or resorption.
  • Bisphosphonates alter osteoclast proton pump function or impair the release of acid hydrolases into the extracellular lysosomes
  • Bisphosphonates inhibit mevalonate synthesis. Mevalonate is critical for osteoblast survival and bone resorption

By above mechanism of action, bisphosphonates help in reducing bone loss and thereby enhance new bone formation indirectly. As new bone mass formation goes on and there is inhibition of bone mass loss or bone resorption, it ultimately leads to increased new bone mass and thereby prevents osteoporosis.

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