Environmental Causes of Type-1 Diabetes

Environmental Causes of Type-1 Diabetes

We know by now that we need to eat the right foods, need to work out, and do stuff that is healthy for us. Because maintaining good health does not happen by accident, it requires work and smart lifestyle choices. But sometimes when we wake up at 6 am to hit the gym before work or shunning the donuts in breakfast, it’s easy to lose sight of for what are we doing all these. So here are some top articles choices that can keep you motivated to lead a healthy lifestyle and keep diseases at bay.

Environmental Causes of Type-1 Diabetes

Environmental factors can trigger and express type-1 diabetes, especially among genetically predisposed individuals. The environmental factors play a major role in causation of type 1 diabetes is clear from the fact that if one identical twin has type 1 diabetes, only 30%-50% of the cases the other twin also has, type 1 diabetes, despite having exactly the same genome or genetic make up. There are various environmental factors that are considered to have role in causation of type-1 diabetes, such as virus, diet, drugs and chemicals etc.

Virus in causation of type-1 diabetes:

There are several viruses (such as rubella virus, Coxsackie virus etc.), which are implicated to have a causative role in type-1 diabetes, but in most cases the evidences are inconclusive. All individuals infected with the above mentioned viruses do not develop type-1 diabetes and it is postulated that genetic predisposition and infection with rubella virus or Coxsackie virus predispose an individual to develop type-1 diabetes and virus acting as trigger.

Diet in causation of type-1 diabetes:

The evidences are growing, that diet is responsible for or plays a role in causation of type-1 diabetes. Most likely diet influence immune function, gut flora and intestinal permeability and play a role in causation of type-1 diabetes.

There are various diet and food items implicated to have a causative role such as wheat, cow’s milk protein (by development of antibodies against cow’s milk protein) etc., as evidenced by higher prevalence of type-1 diabetes among wheat eating population. But the relationship of diet (wheat, cow’s milk protein) and type-1 diabetes is not well understood.

Short breast-feeding period is also implicated to increase the incidence of type-1 diabetes.

Drugs and chemicals in causation of type-1 diabetes:

There are some drugs and chemicals, which can destroy the beta cells of pancreas, which secrete insulin. N-3-pyridylmethyl-N’-p-nitrophenyl urea, a rodenticide (which kills rodents) with brand name Pyrinuron, introduced in the United States in 1976 and withdrawn from market in 1979 is one example of chemical, which can cause type-1 diabetes, which destroy pancreatic beta cells after accidental or intentional ingestion and resulting in type-1 diabetes. Streptozotocin an antibiotic with brand name Zanosar, and anticancer drugs used in pancreatic cancer can destroy pancreatic beta cells and cause type-1 diabetes.

Pancreatic problems such as infection of pancreas (pancreatitis) or any trauma to pancreas can result in total loss of beta cells and result in type-1 diabetes.

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