NSAIDs in Treatment of Osteoarthritis
NSAIDs (Non-steroidal Anti-inflammatory Drugs) are the most effective for reducing pain in osteoarthritis, as they are the best in reducing pain symptom of osteoarthritis and for this reason they are the most popular drugs in management of osteoarthritic pain in most of the patients. NSAIDs produce approximately 30% more pain relief in patients in compare to high dose acetaminophen (paracetamol). Although the result of pain relief is variable, like any other pain relieving drugs, e.g. in some patients NSAIDs produce dramatic pain relief, whereas in some patients NSAIDs may have little effect or may not reduce pain at all.
NSAIDs should be taken “when required†in the early days of treatment and in mild to moderate cases of osteoarthritis. Intermittent doses of NSAIDs are highly efficacious in osteoarthritis, with additional advantage of fewer side effects. If intermittent and low dose is not working, NSAIDs can be used as daily normal anti-inflammatory dose.Categories: General Health Tags: NSAIDS
4th Cause of Acne (out of 4 main causes)
The exact mechanism of inflammation in acne is not clear. A comedone is present in about 88% of inflamed papules and duct rupture is seen in one third of papular in 36 hours after the onset of inflammation. But two third of ducts are ruptured by 72 hours. Inflammatory mediators (interleukins, tumor necrosis factor TNF & prostaglandins) move through the duct into the dermis. The inflammation in dermis is not produced by bacteria but it is most likely due to inflammatory mediators that diffuse from follicles which are produced by the microorganism P. acnes.
Categories: Acne Tags: Complement pathways, Inflammatory mediators, NSAIDS
