Posts Tagged ‘entero-toxigenic Escherichia coli (ETEC)’

Prevention of Traveler’s Diarrhea

Traveler’s diarrhea can be prevented if precautions are observed properly during international travel. The main preventive measures of traveler’s diarrhea are related to food and water precautions. But studies indicate that indiscretion in eating and drinking water is done by approximately 98% of traveler’s upon arrival of their destination within 72 hours. That means only a handful of cautious travelers follow the precautions for prevention of traveler’s diarrhea. No wonder that such a large percentage of travelers suffer from traveler’s diarrhea. There is a popular slogan for travelers “Boil it, cook it, peel it, or forget it!” and it is easier to remember than following it as the studies indicate.

In general a traveler should follow some precautions for prevention of traveler’s diarrhea. The food precautions are eating food when it is still hot, avoid foods that are raw, poorly cooked, or sold by street vendors etc. Water precautions include drinking only boiled or commercially bottled beverages (preferably those that are carbonated). Heating can kill organisms that cause traveler’s diarrhea (entero-toxigenic Escherichia coli, entero-aggregative E. coli, Campylobacter, Salmonella, Shigella, rotavirus, norovirus etc.), but freezing can not kill them and due to this reason ice cubes made from unpurified water should be avoided.

Prophylaxis of traveler’s diarrhea:

The most commonly used prophylaxis for traveler’s diarrhea is bismuth subsalicylate, but it is only 60% effective. In special cases (athletes, persons with a repeated history of travelers’ diarrhea, and persons with chronic diseases) a single daily dose of a quinolone or azithromycin or a once-daily rifaximin regimen during travel of more than 1 month’s duration is effective in preventing travelers’ diarrhea in 75% to 90% of cases.

Self treatment of traveler’s diarrhea:

Ideally all travelers should carry some medication for traveler’s diarrhea for self-treatment, as it can occur despite rigorous food and water precautions. An antibiotic can reduce the frequency of stools and duration of illness in moderate to severe diarrhea. The standard regimen for traveler’s diarrhea is a single daily dose of quinolone (ofloxacin, ciprofloxacin etc.) for 3 successive days. Rifaximin, a poorly absorbed rifampin derivative and is highly effective against noninvasive bacterial pathogens like entero-toxigenic E. coli and entero-aggregative E. coli. But if you acquire traveler’s diarrhea, in Thailand, where more than 90% of Campylobacter infections are quinolone resistant, azithromycin can be a good choice.

Traveler’s Diarrhea

Diarrhea (also known as traveler’s diarrhea) is the leading cause of illness in travelers but it is usually self limiting and short-lived. Approximately 40% of affected travelers need to change their scheduled activities and approximately 20% are confined to bed. For travelers diarrhea, the most important which determines the risk is the destination of the traveler. The rate of incidence of diarrhea among travelers is about 8% in developed countries and as high as 55% or higher in parts of Africa, Central and South America, and Southeast Asia for a 2-week stay. Young people and infants are most vulnerable to get diarrhea. A recent study suggests that there is little correlation between dietary indiscretions (eating what traveler like without thinking of health problems) and the occurrence of travelers’ diarrhea.

The commonest identified pathogens for traveler’s diarrhea are entero-toxigenic Escherichia coli (ETEC) and entero-aggregative E. coli. But in some parts of the world traveler’s diarrhea like northern Africa and Southeast Asia, is due to Campylobacter infections. Other organisms found to cause traveler’s diarrhea are Salmonella, Shigella, rotavirus, and norovirus (this virus has caused numerous outbreaks on cruise ships) etc. Parasitic infections like giardiasis may cause traveler’s diarrhea some times, but other parasitic infections are uncommon causes of travelers’ diarrhea. A huge problem that is emerging in case of travelers’ diarrhea is development of antibiotic resistance among many bacterial pathogens (strains of Campylobacter are resistant to quinolones like ciprofloxacin and strains of E. coli, Shigella, and Salmonella resistant to trimethoprim + sulfamethoxazole combination).

The clinical features of traveler’s diarrhea include frequent stool and some times abdominal pain, but these symptoms disappear within few days (self limiting) even without any treatment. Treatment of traveler’s diarrhea is usually not required in maximum number of patients as it goes off by itself with a few days. The dehydration is usually mild and no aggressive rehydration is not required. If it persists or as a precaution oral rehydration salts (ORS) can be taken as required.